fathmm

Functional Analysis through Hidden Markov Models (v2.3)

A high-throughput web-server capable of predicting the functional consequences of both coding variants, i.e. non-synonymous single nucleotide variants (nsSNVs), and non-coding variants.

Inherited Disease Use this option to return predictions capable of discriminating between disease-causing mutations and neutral polymorphisms.
Cancer Use this option to return predictions capable of distinguishing between cancer-promoting/driver mutations and other germline polymorphisms
Disease-Specific Use this option to return a list of ranked variants that are potentially functionally relevant to to your disease of interest.
Coming Soon!