A high-throughput web-server capable of predicting the functional consequences of both coding variants, i.e. non-synonymous single nucleotide variants (nsSNVs), and non-coding variants in the human genome.
|
|
---|---|
Inherited Disease | Use this option to return predictions capable of discriminating between disease-causing mutations and neutral polymorphisms. |
Cancer | Use this option to return predictions capable of distinguishing between cancer-promoting/driver mutations and other germline polymorphisms |
Disease-Specific | Use this option to return a list of ranked variants that are potentially functionally relevant to to your disease of interest. |
|
|
---|---|
FATHMM-MKL | Our MKL algorithm integrates functional annotations from ENCODE with nucleotide-based HMMs. Use this option to return predictions on both coding and non-coding variants. |
FATHMM-XF | Our XF algorithm incorporates extra features |
|
|
---|---|
CScape | CScape predicts the oncogenic status (disease-driver or neutral) of somatic point mutations |